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Muscle function in women with systemic sclerosis: Association with fatigue and general physical function

  • Amanda Cristina Justo
    Affiliations
    Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Center, Praça das Nações, 34, Bonsucesso, 21041-010 Rio de Janeiro, Brazil
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  • Fernando Silva Guimarães
    Affiliations
    Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Center, Praça das Nações, 34, Bonsucesso, 21041-010 Rio de Janeiro, Brazil
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  • Arthur Sá Ferreira
    Affiliations
    Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Center, Praça das Nações, 34, Bonsucesso, 21041-010 Rio de Janeiro, Brazil
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  • Mauricio Santos Soares
    Affiliations
    Admiral Adalberto Nunes Physical Education Center (Brazilian Navy), Avenida Brasil, 10590, Penha, 21030-001 Rio de Janeiro, Brazil
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  • Priscila Santos Bunn
    Affiliations
    Admiral Adalberto Nunes Physical Education Center (Brazilian Navy), Avenida Brasil, 10590, Penha, 21030-001 Rio de Janeiro, Brazil
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  • Agnaldo José Lopes
    Correspondence
    Corresponding author at: Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Center, Praça das Nações, 34, Bonsucesso, 21041-010 Rio de Janeiro, Brazil.
    Affiliations
    Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Center, Praça das Nações, 34, Bonsucesso, 21041-010 Rio de Janeiro, Brazil

    Postgraduate Programme in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Av. Prof. Manoel de Abreu, 444, Vila Isabel, 20550-170 Rio de Janeiro, Brazil
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      Highlights

      • Systemic sclerosis patients were assessed using knee isokinetic dynamometry.
      • Systemic sclerosis patients have reduced strength and endurance.
      • Systemic sclerosis patients have an imbalance between the quadriceps and hamstrings.
      • Lower muscle strength of the knee joint is associated with lower handgrip strength.
      • Lower muscle strength of the knee joint is associated with physical incapacity.

      Abstract

      Background

      Individuals with systemic sclerosis have muscle functions with varying degrees of muscle weakness and atrophy, which in turn can have a negative impact on functional and health-related quality of life. This study aimed to evaluate peripheral muscle performance using isokinetic dynamometry of the knee in women with systemic sclerosis and to correlate peripheral muscle dysfunction with disability levels and general fatigue.

      Methods

      Twenty-six women with systemic sclerosis and a matched control group with an equal number of women underwent knee isokinetic dynamometry at angular speeds of 75°/s and 240°/s, isometric handgrip strength, the Health Assessment Questionnaire Disability Index, the Functional Assessment of Chronic Illness Therapy-Fatigue scale, and the Fatigue Impact Scale.

      Findings

      Women with systemic sclerosis showed significant reductions in almost all isokinetic parameters for the two angular velocities tested compared with the controls. An agonist/antagonist ratio with values <40% was observed in approximately one-third of the patients. These patients had lower isometric handgrip strength. These patients also performed worse on the two general fatigue scales evaluated. Significant correlations were observed between the isokinetic parameters and the measured isometric handgrip strength, and the Health Assessment Questionnaire Disability Index.

      Interpretation

      Systemic sclerosis patients have reduced strength and endurance as well as a muscle imbalance between the quadriceps and hamstrings. In these patients, lower muscle dysfunction of the knee joint is associated with lower handgrip strength and physical incapacity.

      Keywords

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