Intervertebral disc herniation: studies on a porcine model exposed to highly repetitive flexion/extension motion with compressive force

  • Jack P Callaghan
    Occupational Biomechanics and Safety Laboratories, Faculty of Applied Health Sciences, Department of Kinesiology, University of Waterloo, Waterloo, Ont., Canada N2L 3G1
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  • Stuart M McGill
    Corresponding author
    Occupational Biomechanics and Safety Laboratories, Faculty of Applied Health Sciences, Department of Kinesiology, University of Waterloo, Waterloo, Ont., Canada N2L 3G1
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  • Author Footnotes
    1 Currently at Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ont., Canada N1G 2W1.


      Objective. To determine whether repeated motion with low magnitude joint forces, and flexion/extension moments consistently produce herniation in a non-degenerated, controlled porcine spine motion segment.
      Design. Combined loading (flexion/extension motions and compressive forces) was applied to in vitro porcine functional spinal units. Biomechanical and radiographic characteristics were documented.
      Background. While most studies performed in vitro have examined uniaxial or fixed position loading to older specimens, there have been few studies that have examined whether `healthy' intervertebral discs can be injured by low magnitude repeated combined loading.
      Methods. Porcine cervical spine motion segments (C3–C4) were mounted in a custom jig which applied axial compressive loads with pure flexion/extension moments. Dynamic testing was conducted to a maximum of 86400 bending cycles at a rate of 1 Hz with simultaneous torques, angular rotations, axial deformations recorded for the duration of the test.
      Results. Herniation (posterior and posterior-lateral regions of the annulus) occurred with relatively modest joint compression but with highly repetitive flexion/extension moments. Increased magnitudes of axial compressive force resulted in more frequent and more severe disc injuries.
      Conclusions. The results support the notion that intervertebral disc herniation may be more linked to repeated flexion extension motions than applied joint compression, at least with younger, non-degenerated specimens.Relevance
      While intervertebral disc herniations are observed clinically, consistent reproduction of this injury in the laboratory has been elusive. This study was designed to examine the biomechanical response and failure mechanics of spine motion segments to highly repetitive low magnitude complex loading.


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