Abstract
Background
The wear of the biomaterial/cartilage interface is vital for the development of innovative
chondroplasty therapies. The aim of this study was to investigate potential chondroplasty
biomaterials when sliding against natural articular cartilage under uniaxial reciprocating
and multi-directional rotation/reciprocating motions.
Method
Three biphasic hydrogels were compared to articular cartilage (negative control) and
stainless steel (positive control). Friction was measured by means of a simple geometry
friction and wear simulator. All tests were completed in 25% bovine serum at 20 °C. Mechanical alterations to the surface structure were quantified using surface
topography.
Findings
Articular cartilage produced a constant friction value of 0.05 (confidence interval = 0.015) with and without rotation. Stainless steel against articular cartilage produced
an increase in friction over time resulting in a peak value of 0.7 (confidence interval = 0.02) without rotation, increasing to 0.88 (confidence interval = 0.03) with rotation. All biphasic hydrogels produced peak friction values lower than
the positive control and demonstrated no difference between uni- and multi-directional
motion. Degradation of the opposing cartilage surface showed a significant difference
between the positive and negative controls, with the greater cartilage damage when
sliding against stainless steel under uni-directional motion.
Interpretation
The lower friction and reduction of opposing cartilage surface degradation with the
potential chondroplasty biomaterials can be attributed to their biphasic properties.
This study illustrated the importance of biphasic properties within the tribology
of cartilage substitution materials and future work will focus on the optimisation
of biphasic properties such that materials more closely mimic natural cartilage.
Keywords
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Article info
Publication history
Published online: May 24, 2007
Accepted:
March 21,
2007
Received:
December 20,
2006
The paper is in conjunction with winning the European Society of Biomaterials’ Clinical Biomechanics Award 2006Identification
Copyright
© 2007 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
